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  • Title: Facile synthesis of long-wavelength emission carbon dots for hypochlorite sensing and intracellular pH imaging.
    Author: Meng Y, Wu L, Zhao J, Shuang S, Dong C, Nie J.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2024 Dec 05; 322():124767. PubMed ID: 39013304.
    Abstract:
    Hypochlorite (ClO-), a typical reactive oxygen species, plays an irreplaceable roles in various biological processes. In this work, long-wavelength emission carbon dots (LW-CDs) were fabricated through one-step hydrothermal method by using l-cysteine (cys) and neutral red (NR) as precursors for monitoring of hypochlorite and intracellular pH. Characterizations of as-prepared LW-CDs showed that they had excellent water solubility, high optical stability and sensitive response behavior. Fluorescence intensity of LW-CDs decayed in the presence of ClO- linearly from 10 to 162.5 μM (LOD = 1.021 μM) based on static quenching effect with ideal selectivity. Besides, LW-CDs revealed a pH responsive behavior in the pH range of 2.0 to 10.0, exhibited dual good linear relationships in the pH ranges of 4.2-5.8 and 5.8-7.4. The LW-CDs can also be utilized as imaging reagents in Hela living cells owing excellent biocompatibility and low cytotoxicity. These results demonstrated that the as-mentioned LW-CDs are expected to serve as excellent long wavelength emitting nanomaterials for fluorescence sensing and monitoring of cell fluctuations.
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