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  • Title: Severe protein C deficiency in congenital thrombotic disease--description of an immunoenzymological assay for protein C determination.
    Author: Soria J, Soria C, Samama M, Nicolas G, Kisiel W.
    Journal: Thromb Haemost; 1985 Jun 24; 53(3):293-6. PubMed ID: 3901386.
    Abstract:
    An immunoenzymatic assay (ELISA) is described for the quantitative assay of protein C in plasma. This technique allows a safe, reliable, and sensitive assay of protein C, and is easily used for routine investigation. Using this technique, a protein C deficiency (0.16 U/ml) was discovered in a 16 year old patient with a history of very severe thrombotic disease. Protein C deficiency was also discovered in his mother (0.62 U/ml) and father (0.50 U/ml). We therefore suggest that this case could represent a homozygous deficiency of protein C.
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