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  • Title: [Mutagenic activity of nitrothiazole compounds].
    Author: Hof H.
    Journal: Zentralbl Bakteriol Mikrobiol Hyg B; 1985 Jun; 181(1-2):64-70. PubMed ID: 3901605.
    Abstract:
    The mutagenic activities of different nitrothiazole derivatives were examined by the Ames-test. Such nitrothiazoles which display pronounced antibacterial properties against aerobic as well as anaerobic bacteria exert strong mutagenic activities. Thereby, both base pair substitution and frame-shift mutation occur. Reduction of the nitro-group of the nitrothiazoles by bacterial nitroreductases is a prerequisite for these mutagenic activities. In contrast, nitrothiazole derivatives which are unable to inhibit bacterial multiplication are also not mutagenic.
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