These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Dosimetry of microbeam radiotherapy by flexible hydrogenated amorphous silicon detectors.
    Author: Large MJ, Kanxheri K, Posar J, Aziz S, Bashiri A, Calcagnile L, Calvo D, Caputo D, Caricato AP, Catalano R, Cirio R, Cirrone GAP, Croci T, Cuttone G, De Cesare G, De Remigis P, Dunand S, Fabi M, Frontini L, Grimani C, Guarrera M, Ionica M, Lenta F, Liberali V, Lovecchio N, Martino M, Maruccio G, Mazza G, Menichelli M, Monteduro AG, Morozzi A, Moscatelli F, Nascetti A, Pallotta S, Passeri D, Pedio M, Petringa G, Peverini F, Placidi P, Quarta G, Rizzato S, Sabbatini F, Servoli L, Stabile A, Thomet JE, Tosti L, Villani M, Wheadon RJ, Wyrsch N, Zema N, Petasecca M, Talamonti C.
    Journal: Phys Med Biol; 2024 Jul 26; 69(15):. PubMed ID: 39019068.
    Abstract:
    Objective.Detectors that can provide accurate dosimetry for microbeam radiation therapy (MRT) must possess intrinsic radiation hardness, a high dynamic range, and a micron-scale spatial resolution. In this work we characterize hydrogenated amorphous silicon detectors for MRT dosimetry, presenting a novel combination of flexible, ultra-thin and radiation-hard features.Approach.Two detectors are explored: an n-type/intrinsic/p-type planar diode (NIP) and an NIP with an additional charge selective layer (NIP + CSC).Results.The sensitivity of the NIP + CSC detector was greater than the NIP detector for all measurement conditions. At 1 V and 0 kGy under the 3T Cu-Cu synchrotron broadbeam, the NIP + CSC detector sensitivity of (7.76 ± 0.01) pC cGy-1outperformed the NIP detector sensitivity of (3.55 ± 0.23) pC cGy-1by 219%. The energy dependence of both detectors matches closely to the attenuation coefficient ratio of silicon against water. Radiation damage measurements of both detectors out to 40 kGy revealed a higher radiation tolerance in the NIP detector compared to the NIP + CSC (17.2% and 33.5% degradations, respectively). Percentage depth dose profiles matched the PTW microDiamond detector's performance to within ±6% for all beam filtrations except in 3T Al-Al due to energy dependence. The 3T Cu-Cu microbeam field profile was reconstructed and returned microbeam width and peak-to-peak values of (51 ± 1)μm and (405 ± 5)μm, respectively. The peak-to-valley dose ratio was measured as a function of depth and agrees within error to the values obtained with the PTW microDiamond. X-ray beam induced charge mapping of the detector revealed minimal dose perturbations from extra-cameral materials.Significance.The detectors are comparable to commercially available dosimeters for quality assurance in MRT. With added benefits of being micron-sized and possessing a flexible water-equivalent substrate, these detectors are attractive candidates for quality assurance,in-vivodosimetry and in-line beam monitoring for MRT and FLASH therapy.
    [Abstract] [Full Text] [Related] [New Search]