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  • Title: Effect of ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation on gastrointestinal reactions of malignant tumor patients undergoing chemotherapy.
    Author: Zhuang Y, Yu DD, Ma TT, Wang YX, Wang YY, Luo L, Shi B.
    Journal: Zhen Ci Yan Jiu; 2024 Jul 25; 49(7):700-706. PubMed ID: 39020488.
    Abstract:
    OBJECTIVES: To observe the efficacy and safety of ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in patients with malignant tumors. METHODS: Patients with malignant tumors and suffering from chemotherapy were randomly divided into control group (35 cases, 4 cases dropped off) and observation group (35 cases, 2 cases dropped off). The patients of the control group were treated by orally taking ondansetron hydrochloride tablets 8 mg/time, 3 times a day for 3 d, and those of the observation group treated by ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation of Zusanli(ST36), Neiguan(PC6), Tianshu(ST25), Zhongwan(CV12) and Guanyuan(CV4) once a day for a total of 3 d, based on the treatment of the control group. The patients' gastrointestinal reaction degree after the 1st , 2nd and the 3rd day of treatment were recorded. The Karnofsky performance status (KPS) score (0-100 points) was used for assessing the patients' quality of life. The TCM syndrome score (4 grades：no, mild, medium and severe, i.e. 0, 2, 4 and 6 points) was given according to the patients' severity of symptoms of spleen (stomach) qi deficiency (nausea and vomiting, abdominal distension after eating, belching, loss of appetite, weakness and laziness to speak, fatigue, and loose stool). The safety of the treatment was assessed by examining the patients' blood routine, liver function and kidney function, and the adverse reactions including blisters, allergies, burns and fainting during acupuncture treatment. RESULTS: After the 2nd and 3rd day of treatment, the patients conditions of vomiting and nausea in the observation group were significantly better than those of the control group (P<0.05). The TCM syndrome score and KPS score were significantly decreased in comparison with those of pre-treatment in both groups (P<0.05), and the TCM syndrome score was obviously lower in the observation group than in the control group (P<0.05). No significant differences were found between the two groups in the KPS score after the treatment , and in the levels of white blood cells (WBC), hemoglobin (HGB), platelets (PLT), absolute neutrophil count (ANC), alanine transaminase (ALT), aspartate aminotransferase (AST), creatinine(Cr), and blood urea nitrogen (BUN). CONCLUSIONS: The use of ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation is safe for CINV patients, and can effectively relieve nausea and vomiting and alleviate digestive symptoms. 目的: 观察隔姜灸联合揿针防治恶性肿瘤患者化疗所致恶心呕吐（CINV）的有效性和安全性。方法: 恶性肿瘤化疗患者随机分为对照组（35例，退出和脱落4例）和观察组（35例，退出2例）。对照组给予盐酸昂丹司琼片8 mg口服，每日3次，共治疗3 d；观察组在对照组的基础上取足三里、内关、天枢、中脘、关元行隔姜灸联合揿针治疗，每日1次，共治疗3 d。观察两组患者治疗第1、2、3天后消化道反应程度，治疗前后的卡氏（KPS）评分、中医证候评分及相关安全性指标。结果: 观察组治疗第2、3天的消化道反应程度优于对照组（P<0.05）。治疗后，两组患者中医证候评分较治疗前均降低（P<0.01），观察组低于对照组（P<0.01）。治疗后，两组患者的KPS评分均低于治疗前（P<0.01）。两组患者均未出现明显不良反应。结论: 在常规止吐方案的基础上，采用隔姜灸联合揿针疗法治疗CINV舒适安全，能有效缓解患者的恶心呕吐，减轻消化系统症状。.
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