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  • Title: Multiple alpha-keto aciduria in Microtus montanus chronically infected with Trypanosoma brucei gambiense.
    Author: Hall JE, Seed JR, Sechelski JB.
    Journal: Comp Biochem Physiol B; 1985; 82(1):73-8. PubMed ID: 3902349.
    Abstract:
    Microtus montanus chronically infected with a monomorphic strain of Trypanosoma brucei gambiense excreted in urine greatly elevated quantities of not only the aromatic alpha-keto acids, phenylpyruvic and 4-hydroxyphenylpyruvic acids, but also two aliphatic alpha-keto acids, pyruvic and alpha-ketoglutaric acids. Elevated keto acid excretion began approximately midway through infection and quantities remained elevated until death. Daily keto acid excretion did not correlate with daily parasitemia. Thus, a large metabolic disturbance exists in laboratory animals infected with African trypanosomes. The multiple alpha-keto aciduria potentially contributes to the pathogenesis of chronic African trypanosomiasis.
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