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  • Title: The effect of potassium, calcium and magnesium concentration on insulin and glucagon secretion of the perfused dog pancreas.
    Author: Panzig E, Besch W, Rosenbaum KD, Tietz W, Kiene S, Wolf E, Paul W.
    Journal: Exp Clin Endocrinol; 1985 Aug; 86(1):61-8. PubMed ID: 3902485.
    Abstract:
    The effect of different potassium, calcium and magnesium concentrations in the perfusate on the hormone secretion of the isolated dog pancreas was investigated. A potassium concentration above 15 mMol/l shortly stimulates the insulin and glucagon secretion. Potassium ions (greater than or equal to 15 mMol/l) completely inhibit the early phase of glucose-induced insulin release. At a low Ca2+-level (0.25 mMol/l) the glucose-stimulated insulin secretion is reduced to basal values. On the other hand, the glucagon release is stimulated under these conditions. An increase of magnesium ions from 1.0 mMol/l to 2.5-7.5 mMol/l strikingly inhibits insulin and glucagon release by approximately 50%, which is compensated for insulin by increasing the Ca2+-content of the medium. Perfusates for normothermic pancreas perfusion should contain electrolyte concentrations within the physiological range.
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