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  • Title: The synthesis and mutagenicity of the 3-ethyl analogues of the potent mutagens IQ, MeIQ, MeIQx and its 3,7-dimethyl isomer.
    Author: Jägerstad M, Grivas S.
    Journal: Mutat Res; 1985 Nov; 144(3):131-6. PubMed ID: 3903482.
    Abstract:
    The title compounds were synthesized and tested for mutagenicity on Salmonella typhimurium TA98 in the presence of S9 mix. All test compounds showed lower activity than their respective 3-methyl analogues (IQ compounds). The replacement of the 3-methyl by an ethyl group should not alter the chemistry of these compounds; hence, their lower mutagenic activity could merely be of steric origin.
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