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  • Title: Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test.
    Author: Yamanaka H, Nagao M, Sugimura T, Furuya T, Shirai A, Matsushima T.
    Journal: Mutat Res; 1979 Nov; 68(3):211-6. PubMed ID: 390394.
    Abstract:
    The mutagenicities of 7 pyrrolizidine alkaloids to Salmonella typhimurium TA100 were demonstrated by a modified Ames's method. The pyrrolizidine alkaloids found to be mutagenic were clivorine, fukinotoxin, heliotrine, lasiocarpine, ligularidine, LX201 and senkirkine. Pre-incubation of these alkaloids with S9 mix and bacteria in a liquid medium was essential for demonstration of their mutagenicities.
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