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  • Title: [Antiherpetic activity of xylure].
    Author: Chekunova EV, Marennikova SS, Mel'nik SIa, Preobrazhenskaia MN, Zaguliaeva OA.
    Journal: Vopr Virusol; 1985; 30(4):444-6. PubMed ID: 3904209.
    Abstract:
    In vivo experiments demonstrated antiherpetic activity of abnormal nucleoside, 5-trimethylsylil-2'-deoxyuridine alpha-anomer. In a model of herpetic encephalitis in cotton rats the preparation, inoculated intraperitoneally and administered orally, reduced the lethality by 25%-30% as compared with the controls, and also was effective in topical treatment of genital herpes in guinea pigs. Low toxicity, clear-cut antiherpetic activity, favourable metabolic properties as compared with known antiherpetic drugs indicate the necessity of further thorough investigation of this preparation.
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