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  • Title: Stimulation of prostacyclin production by vitamin C in ram seminal vesicle microsomes: possible mode of action.
    Author: Beetens JR, Van Hoydonck AE, Herman AG.
    Journal: Arch Int Pharmacodyn Ther; 1985 Sep; 277(1):56-65. PubMed ID: 3904652.
    Abstract:
    The enhancing effect of vitamin C on the conversion of arachidonic acid, endoperoxide G2 and endoperoxide H2 to 6-keto-PGF 1 alpha, the stable metabolite of prostacyclin, by ram seminal vesicle microsomes was further investigated. From the incubations of these substrates with 1-tryptophan, catalase, superoxide dismutase and 15-HPETE it became clear that vitamin C apparently acts mainly through neutralization of the oxidative species formed during the reduction of endoperoxide G2 to endoperoxide H2. Although it has also a more direct stimulating activity on the prostacyclin synthase, a possible interference with hydroperoxy derivatives of arachidonic acid cannot be completely ruled out.
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