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  • Title: A multicentre prospective randomized controlled trial of induction of labour with an automatic closed-loop feedback controlled oxytocin infusion system.
    Author: Steer PJ, Carter MC, Choong K, Hanson M, Gordon AJ, Pradhan P.
    Journal: Br J Obstet Gynaecol; 1985 Nov; 92(11):1127-33. PubMed ID: 3904817.
    Abstract:
    A randomized prospective controlled trial of an automatic feed-back controlled oxytocin infusion system (AIS) for the induction of labour at term was carried out in three hospitals. In primiparae, a four-fold reduction in the total dose of oxytocin infused, for the same induction-delivery interval, was achieved with the AIS compared with standard labour ward protocols relying on midwife control of oxytocin infusion rate. In multiparae, the total dose of oxytocin infused was almost halved when the AIS was used, while the mean duration of labour was increased by 1.6 h to 7.5 h. There were no differences in the mode of delivery or Apgar scores. It is concluded that the AIS is a safe technique for induction of labour. Its use has demonstrated that term labour can be induced efficiently with a mean oxytocin infusion rate between 2.5 and 3 mU/min (max 8.8 mU/min) and a total oxytocin dose infused of less than 5 U.
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