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  • Title: Effects of endotoxin and sodium salicylate on the preoptic thermosensitive neurons in tissue slices.
    Author: Nakashima T, Hori T, Kiyohara T, Shibata M.
    Journal: Brain Res Bull; 1985 Nov; 15(5):459-63. PubMed ID: 3904925.
    Abstract:
    Effects of E. coli endotoxin and sodium salicylate (Sal) on single-unit activity of thermosensitive neurons recorded in slices of preoptic and anterior hypothalamic area (PO/AH) were studied in vitro. Perfusion of endotoxin-containing Krebs-Ringer's solution or local application of endotoxin in the immediate vicinity of recording neurons decreased and increased the firing rate of 31 of 34 warm-sensitive neurons and a cold-sensitive neuron, but had no effect on the majority of thermally insensitive neurons. In about half of warm-sensitive neurons the inhibitory response to endotoxin was preceded by a transient increase in firing rate. The pyrogen-induced decrease in firing rate in warm-sensitive neurons was reversibly blocked or attenuated by local application of Sal in a dose-dependent manner. The results are consistent with the view that pyrogen and Sal act in the PO/AH to produce fever and antipyresis, respectively, by appropriately offsetting the activity of thermosensitive neurons.
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