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  • Title: The synthesis of lipids from [1-14C]acetate by isolated rat brain capillaries.
    Author: Homayoun P, Roux F, Niel E, Bourre JM.
    Journal: Neurosci Lett; 1985 Nov 20; 62(1):143-7. PubMed ID: 3906444.
    Abstract:
    Lipid biosynthesis was investigated in isolated cerebral microvessels obtained from adult Sprague-Dawley rats using [1-14C]acetate as precursor. All lipid classes were labelled by [1-14C]acetate. Neutral lipids incorporated about 50% of radiolabelled acetate, among which free fatty acids and triglycerids showed the highest level of incorporation. Moreover, about 4% of radioactivity was found in cholesterol fraction. In phospholipid fraction, phosphatidylcholine and phosphatidylethanolamine were the main radiolabelled phospholipids. [1-14C]acetate was also incorporated into sulphatides and cerebrosides. The presence of bovine serum albumin in incubation medium modified the percentage of incorporation in different lipid fractions.
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