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  • Title: Magnesium-sensitive guanylate cyclase and its endogenous activating factor in Tetrahymena pyriformis.
    Author: Nakazawa K, Shimonaka H, Nagao S, Kudo S, Nozawa Y.
    Journal: J Biochem; 1979 Aug; 86(2):321-4. PubMed ID: 39068.
    Abstract:
    Guanylate cyclase [EC 4.6.1.2] activity in Tetrahymena pyriformis cells was associated with particulate fractions, but not with soluble fractions. Mg2+ was much more effective than Mn2+ in activating the cyclase activity. Both specific and total cyclase activities with Mg2+ in the particulate fraction were very much lower than those in the original homogenate. The addition of the soluble fraction resulted in a marked enhancement of the particulate-bound cyclase activity, while the adenylate cyclase [EC 4.6.1.1] activity was not enhanced. The enhancement was dependent on Ca2+, and the activating factor is suggested to be a protein.
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