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  • Title: [Metabolism of 18S-rRNA in rat liver cells in different functional states of the protein-synthesizing apparatus].
    Author: Chirkov GP, Druzhinina MK, Todorov IN.
    Journal: Biokhimiia; 1985 Oct; 50(10):1587-90. PubMed ID: 3907722.
    Abstract:
    The ratio of absolute radioactivities of 28S and 18S ribosomal RNA in membrane-bound and free polysomes and in free ribosomes of rat liver were studied under conditions of translation inhibition by cycloheximide, insulin and cAMP. Insulin and cAMP, in contrast with cycloheximide, did not induce selective degradation of 18S-rRNA. The data obtained are discussed in terms of the feasible role of S6 protein phosphorylation in degradation of the 40S ribosomal subunit.
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