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  • Title: Prophylactic single-dose co-trimoxazole for prevention of urinary tract infection after abdominal hysterectomy.
    Author: Jaffe R, Altaras M, Fejgin M, Ben-Aderet N.
    Journal: Chemotherapy; 1985; 31(6):476-9. PubMed ID: 3908009.
    Abstract:
    The efficacy of a preoperative single-dose of co-trimoxazole in reducing postoperative urinary tract infection and febrile morbidity after abdominal hysterectomy was evaluated in a randomized placebo-controlled study of 90 patients undergoing surgery. Among the co-trimoxazole patients, 6.2% developed urinary tract infection compared to 31% in the placebo group (p less than 0.001) and 12.5% febrile morbidity compared to 38% in the placebo patients (p less than 0.025). No adverse side effects of co-trimoxazole were observed and this regimen seems both safe and effective.
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