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  • Title: [Synthesis and in vitro antimicrobial activity of N-substituted derivatives of phenylpiperidine and phenylpiperazine].
    Author: Morlacchi F, Trapani G, Losacco V, Armenise D.
    Journal: Farmaco Sci; 1985 Sep; 40(9):671-82. PubMed ID: 3908142.
    Abstract:
    Synthesis and antimicrobial activity of some N-substituted aza- and diaza-phenylcycloalkanes are reported. All the compounds screened in vitro show significant antibacterial and antimycotic activities. Particularly, compounds of the N-(ethoxymethyl)phenylpiperidine series, show activity towards S. aureus 1,2-1,9 superior to ampicillin. Furthermore the microbiological results indicate that the latter activity depends on the position of the phenyl-substituent.
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