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  • Title: Near-Infrared Fluorescent Probe for the Detection of Cysteine.
    Author: Wang M, Yang X, Yuan M, Zhou W, Yang L.
    Journal: Appl Spectrosc; 2024 Jul; 78(7):744-752. PubMed ID: 39096170.
    Abstract:
    Hemicyanine dyes are an ideal structure for building near-infrared fluorescent probes due to their excellent emission wavelength properties and biocompatibility in biological imaging field. Developing a near-infrared fluorescent probe capable of detecting cysteine (Cys) was the aim of this study. A novel developed fluorescent probe P showed high selectivity and sensitivity to Cys in the presence of various analytes. The detection limit of P was found to be 0.329 μM. The MTT assay showed that the probe was essentially non-cytotoxic. Furthermore, the probe was successfully used as cysteine imaging in living cells and mice.
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