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  • Title: Misonidazole and hemibody irradiation in the palliation of widespread metastases. Final report of an RTOG study.
    Author: Zagars G, Salazar OM, Baird M, Phillips TL, Rubin P.
    Journal: Am J Clin Oncol; 1985 Aug; 8(4):293-7. PubMed ID: 3909800.
    Abstract:
    The radiation therapy oncology group conducted a phase I/II trial of hemibody irradiation combined with high-dose misonidazole in the management of metastatic solid tumors. Thirty-seven patients received 39 hemibody irradiation treatments, each preceded by 4 g/m2 or 5 g/m2 misonidazole orally. One fraction of 600 cGy was delivered to a half-body volume. Objective tumor response occurred in 21% of evaluable patients, including one complete response. Pain relief was documented in only 36%. Acute toxicity consisting of nausea and vomiting was significant; 54% of patients experienced severe or very severe reactions. Other toxicities were acceptable. The low response rate and high acute toxicity contraindicate the use of misonidazole with hemibody irradiation for palliation.
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