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  • Title: Are vascular mechanisms involved in antidepressant action?
    Author: DeFeudis FV.
    Journal: Gen Pharmacol; 1985; 16(6):553-6. PubMed ID: 3910516.
    Abstract:
    Recent studies of the mechanisms of action of certain antidepressants, anti-migraine agents, and Ca2+ entry blockers have been briefly reviewed and analyzed. It is postulated that a thorough explanation of the therapeutic effects of antidepressants should include discussion of their actions on the cardiovascular (cerebrovascular) system. The inhibitory actions of antidepressants on Ca2+- and serotonin (5-HT)-mediated processes of vascular smooth muscle seem to be particularly important.
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