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  • Title: Single-Atom Fe-Catalyzed Acceptorless Dehydrogenative Coupling to Quinolines.
    Author: Lu Y, Zhu M, Chen S, Yao J, Li T, Wang X, Tang C.
    Journal: J Am Chem Soc; 2024 Aug 21; 146(33):23338-23347. PubMed ID: 39105742.
    Abstract:
    A single-atom iron catalyst was found to exhibit exceptional reactivity in acceptorless dehydrogenative coupling for quinoline synthesis, outperforming known homogeneous and nanocatalyst systems. Detailed characterizations, including aberration-corrected HAADF-STEM, XANES, and EXAFS, jointly confirmed the presence of atomically dispersed iron centers. Various functionalized quinolines were efficiently synthesized from different amino alcohols and a range of ketones or alcohols. The iron single-atom catalyst achieved a turnover number (TON) of up to 105, far exceeding the results of current homogeneous and nanocatalyst systems. Detailed mechanistic studies verified the significance of single-atom Fe sites in the dehydrogenation process.
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