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  • Title: Successful treatment of intestinal malakoplakia in a French Bulldog.
    Author: Namiki K, Mizoguchi H, Fujita N, Takahashi M, Kagawa Y.
    Journal: J Vet Med Sci; 2024 Sep 10; 86(9):974-978. PubMed ID: 39111849.
    Abstract:
    Malakoplakia is a rare granulomatous inflammation that has mainly been reported in the urinary bladder of dogs. Only one case of canine colonic malakoplakia has been reported to date; however, successful treatment of this disease has not been reported. Here, we report a case of colonic malakoplakia in a 5-month-old spayed female French Bulldog. The dog was referred to a veterinarian because of chronic diarrhea and mucinous blood feces; empirical treatment did not improve its condition. Histologically, numerous macrophages containing periodic acid-Schiff-positive granules infiltrated the lamina propria of the large intestine. Furthermore, targetoid basophilic inclusion bodies (Michaelis-Gutmann bodies) were observed. Complete clinical remission was achieved after 8 months of enrofloxacin treatment and favorable progress after 2 months of medication.
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