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  • Title: Comparative Evaluation of the Radioprotective Properties of Copper Chlorophyllin, Trolox, and Indralin in an Experiment on Mice.
    Author: Romodin LA, Nikitenko OV, Bychkova TM, Zrilova YA, Rodionova ED, Bocharov DA.
    Journal: Bull Exp Biol Med; 2024 Jul; 177(3):328-332. PubMed ID: 39126544.
    Abstract:
    The radioprotective properties of copper chlorophyllin (100 and 150 μg/g), the standard antioxidant trolox (100 and 200 μg/g), and the standard radioprotector indralin (100 and 150 μg/g) were compared in male ICR mice (CD-1) subjected to whole-body irradiation (X-ray radiation) in doses of 6, 6.5, and 6.75 Gy. Animal survival was analyzed using the Kaplan-Meier method, and the significance of differences was evaluated using the log-rank test method. Dose change factors determined using the Phinney probit analysis were 1.1, 1.0, and 1.8 for chlorophyllin, trolox, and indralin at a dose of 100 μg/g body weight, respectively. The insignificant radioprotective properties of chlorophyllin and their absence in trolox when administered prophylactically do not rule out their possible radioprotective properties like a radiomodulator that protects the body after irradiation.
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