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  • Title: Medullary nephrocalcinois and primary hyperaldosteronism - A rare and under recognised association.
    Author: John R, Johnson JT, Rajan RR, Jebasingh F.
    Journal: J Postgrad Med; 2024 Jul 01; 70(3):166-168. PubMed ID: 39132858.
    Abstract:
    Medullary nephrocalcinosis is an uncommon manifestation of primary hyperaldosteronism (PHA) and the exact etiology of this association is still debated. Here we report three cases of PHA with medullary nephrocalcinosis and how medullary nephrocalcinosis in one patient led to misdiagnosis as renal tubular acidosis (RTA). Although PHA and RTA can share overlapping symptoms, careful evaluation of clinical presentation, biochemical tests, and imaging studies are essential to differentiate between the two conditions and ensure appropriate management. Also, awareness of this uncommon manifestation of PHA is essential to avoid misdiagnosis as tubulopathy, as this may delay the treatment.
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