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  • Title: Measurement of glomerular filtration rate by means of a 99Tcm-DTPA complex and a scintillation camera: a method based on the kinetics of the distribution volume of the tracer in the kidney area.
    Author: Delcourt E, Franken P, Motte S, Van Calck M.
    Journal: Nucl Med Commun; 1985 Dec; 6(12):787-94. PubMed ID: 3913888.
    Abstract:
    Glomerular filtration rate (GFR) may be computed using the kinetics of the renal distribution volume curve Vt = Rt/Pt and a power fit of the plasma curve Pt = Pot-B. It can be demonstrated that GFR = d(Vt)/d(t)(1-B). The method is largely independent of background subtraction, allowing nonequivocal renal function determination in all cases. In a preliminary series of 20 patients, the linear regression coefficient of computed GFR with true clearance measurement by multiple blood samples method was 0.97 with a standard error on the estimate of the clearance of 5.5 ml.
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