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  • Title: The incidence of naturally-occurring primary brain tumours in the laboratory rat.
    Author: Krinke G, Naylor DC, Schmid S, Fröhlich E, Schnider K.
    Journal: J Comp Pathol; 1985 Apr; 95(2):175-92. PubMed ID: 3915749.
    Abstract:
    Histological analysis of 90 spontaneous primary tumours of the brain observed among 8960 ageing rats (Sprague-Dawley-derived) revealed 55 granular-cell meningiomas, 19 neoplastic reticuloses, 11 neuroglial tumours, 4 pineal tumours, and one pleomorphic, meningeal sarcoma. Although all these tumour types can occur in man and other animal species, the high incidence of granular-cell tumours, and the low degree of differentiation of some neuroglial and pineal tumours, appear to be characteristic attributes of the rat.
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