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  • Title: Histopathology of the temporal bone in osteogenesis imperfecta congenita: a report of 5 cases.
    Author: Berger G, Hawke M, Johnson A, Proops D.
    Journal: Laryngoscope; 1985 Feb; 95(2):193-9. PubMed ID: 3918222.
    Abstract:
    The histopathologic findings in 8 temporal bones from 5 patients with osteogenesis imperfecta congenita are reported. The otic capsule, bony walls of middle ear, and ossicles showed evidence of both deficient and abnormal ossification. Microfractures were found in the otic capsule and in the anterior process and handle of the malleus, in addition to their common location at the crura of the stapes. The cochlear and vestibular end-organs appeared normal. Pathologic changes compatible with otosclerosis were not seen. The possible implication of these changes on hearing and balance is discussed.
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