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  • Title: Plasma follicle-stimulating hormone, luteinizing hormone, and sex hormones in patients with gout.
    Author: Marinello E, Riario-Sforza G, Marcolongo R.
    Journal: Arthritis Rheum; 1985 Feb; 28(2):127-31. PubMed ID: 3918542.
    Abstract:
    Plasma levels of follicle-stimulating hormone, luteinizing hormone, testosterone, progesterone, 17 beta-estradiol, and cortisol were examined in normal subjects and gout patients under baseline conditions and after clomiphene stimulation. A significant decrease in follicle-stimulating hormone, luteinizing hormone, and 17 beta-estradiol was observed both in male and female gout patients; in the same patients, the plasma testosterone: 17 beta-estradiol ratio was found to be significantly higher than in control subjects. The changes observed suggest a possible role played by 17 beta-estradiol in the regulation of purine biosynthesis and uric acid metabolism.
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