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  • Title: Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells.
    Author: Ando I, Hariri G, Wallace D, Beverley P.
    Journal: Eur J Immunol; 1985 Feb; 15(2):196-9. PubMed ID: 3918872.
    Abstract:
    The tumor promoter 12-O-tetradecanoylphorbol 13-acetate induces the expression of the interleukin 2 receptor and the disappearance of the T3 complex in a T cell hybridoma, T cell clones, thymic and peripheral T cells and T cell tumors. These changes are accompanied by an increased sensitivity to interleukin 2 and antigen-specific unresponsiveness in T cell clones.
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