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  • Title: Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes.
    Author: Butler J, Hoey BM, Swallow AJ.
    Journal: FEBS Lett; 1985 Mar 11; 182(1):95-8. PubMed ID: 3918891.
    Abstract:
    The rates of reaction of the semiquinone radicals of adriamycin and mitomycin C with oxygen and several iron (III) complexes have been determined. These rates have been used to explain enhanced free radical damage produced by semiquinone radicals in a model system and to assess the feasibility of these types of reactions occurring in hypoxic cells.
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