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  • Title: Pharmacologic evidence for specificity of pursuit dysfunction to schizophrenia. Lithium carbonate associated with abnormal pursuit.
    Author: Levy DL, Dorus E, Shaughnessy R, Yasillo NJ, Pandey GN, Janicak PG, Gibbons RD, Gaviria M, Davis JM.
    Journal: Arch Gen Psychiatry; 1985 Apr; 42(4):335-41. PubMed ID: 3919684.
    Abstract:
    Conflicting findings regarding the prevalence of abnormal smooth-pursuit eye movements in patients with major affective disorders call into question the specificity of impaired smooth-pursuit eye movements to schizophrenia. We report that pursuit is impaired in 88% of lithium carbonate-treated affective disorder patients whose pursuit was normal prior to receiving this drug. Over half of lithium carbonate-treated affective disorder patients in remission also showed impairment of smooth-pursuit eye movements. In conjunction with recent prevalence data on family members of psychiatric patients, the findings support the specificity of abnormal pursuit as a biological trait associated with schizophrenia, but not with the major affective disorders. The mechanisms by which lithium carbonate impairs pursuit are discussed.
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