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Title: Common variable immune deficiency syndrome associated with lupus anticoagulant. Author: Ruggieri AP, Galbraith RM, Lazarchick J. Journal: Clin Exp Rheumatol; 1985; 3(1):71-3. PubMed ID: 3919983. Abstract: A patient with an acquired immune deficiency syndrome developed a lupus anticoagulant in which the inhibitory activity was manifested only as a prolongation of the partial thromboplastin time. Contrary to previous reports, the substitution of platelets or platelet sonicates for phospholipid in this coagulant assay failed to correct the abnormality and the inhibitor did not exhibit immunoreactivity against phospholipids. The possible mechanisms of action of these inhibitors are discussed.[Abstract] [Full Text] [Related] [New Search]