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  • Title: Bactericidal activity of phenoxymethylpenicillin in an in-vitro model simulating tissue kinetics.
    Author: Sous H, Hirsch I.
    Journal: J Antimicrob Chemother; 1985 Jan; 15 Suppl A():233-9. PubMed ID: 3920182.
    Abstract:
    The antibacterial efficacy of phenoxymethylpenicillin (Pen-V-K) against strains of Staphylococcus aureus was assessed in an in-vitro kinetic model. Simulation was based on human serum levels and tissue water curves obtained after a single oral dose of 392.2 mg of the drug. Differences in bacterial elimination kinetics were noted depending upon the type of curve (serum or tissue water) being simulated.
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