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  • Title: Variation in size of the 'readily releasable pool' of luteinizing hormone during the oestrous cycle of the rat.
    Author: Pickering AJ, Fink G.
    Journal: J Endocrinol; 1979 Oct; 83(1):53-9. PubMed ID: 392040.
    Abstract:
    The size of the 'readily releasable pool' of luteinizing hormone at various times of the oestrous cycle has been determined by injecting a supramaximal dose of luteinizing hormone releasing factor (LH-RF) i.v. into rats anaesthetized with sodium pentobarbitone. In an attempt to block replenishment of the 'pool' during release, cycloheximide was administered 30 min before LH-RF. A 20-fold increase in pool size occurred between the morning of dioestrus and the evening of pro-oestrus in the absence of any significant change in total pituitary content of LH. This suggests that increased responsiveness may be brought about by a change in the receptor-release apparatus and/or a transfer of LH from a 'storage pool' which leads to an apparent increase in the proportion of LH available for release.
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