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  • Title: Effects of maternal ethanol infusion on fetal cardiovascular and brain activity in lambs.
    Author: Patrick J, Richardson B, Hasen G, Clarke D, Wlodek M, Bousquet J, Brien J.
    Journal: Am J Obstet Gynecol; 1985 Apr 01; 151(7):859-67. PubMed ID: 3920909.
    Abstract:
    Ethanol (1 gm/kg of maternal body weight administered over 1 hour) was infused intravenously into 11 chronically prepared pregnant ewes between 128 to 137 days' gestation. Fetal breathing movements were suppressed for 9 hours following ethanol administration, and both high- and low-voltage fetal electrocortical activity were suppressed for 3 hours and replaced by intermediate-voltage electrocortical activity. Fetal blood gases and pH were not altered. These data support the hypothesis that ethanol suppresses fetal breathing movements by a direct central mechanism rather than indirectly by alteration of electrocortical activity.
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