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  • Title: [Regulator mutants for the synthesis of a 2d purine nucleoside phosphorylase in Escherichia coli K-12. II. Mapping and study of the dominance of pndR mutations].
    Author: Kocharian AM, Melkumian MA, Kocharian ShM.
    Journal: Genetika; 1985 Feb; 21(2):220-8. PubMed ID: 3921429.
    Abstract:
    The synthesis of a second purine nucleoside phosphorylase (PNPII) in the wild type strains of Escherichia coli K-12 is induced by xanthosine. Three types of pndR mutants were studied, which are altered in regulation of PNPII synthesis: 1) constitutive, 2) inducible by nucleosides of hypoxantine and adenine as much as by xanthosine and 3) defective in synthesis of PNPII. All pndR mutations are located in transductional crosses on 51 min of E. coli genetic map. The order of genes established is as follows: pndR-ptsH-cysA. Mutations of the first and second type are dominant, while pndR21 mutation of the third type is recessive to the pndR+ allele on F' episome. The data obtained support the suggestion that the product of pndR regulatory gene is an activator protein necessary for the expression of the PNPII structural gene.
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