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  • Title: Crystallization of excipients in tablets.
    Author: Ando H, Watanabe S, Ohwaki T, Miyake Y.
    Journal: J Pharm Sci; 1985 Feb; 74(2):128-31. PubMed ID: 3921688.
    Abstract:
    Whisker-like crystals appeared on the surface of tablets that contained lactose or mannitol, a hygroscopic material such as docusate sodium, magnesium chloride, or potassium acetate, and other ingredients stored in an atmosphere of high relative humidity. The crystals were observed under a scanning electron microscope and were measured using differential scanning calorimetry and TLC. The crystals contained lactose or mannitol.
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