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  • Title: [Cytological and insulin-producing characteristics of cultures of pancreatic islet cells from newborn piglets].
    Author: Komissarenko VP, Turchin IS, Lazareva NP, Tishchenko AV, Onishchenko DS.
    Journal: Probl Endokrinol (Mosk); 1985; 31(2):65-8. PubMed ID: 3921958.
    Abstract:
    The paper is concerned with the characteristics of morphological changes and insulin producing activity of neonatal pig islet cell initial cultures in health and in different glucose concentrations. The investigated cultures preserve morphological and functional differentiation within 4-5 weeks of growth. Insulin biosynthesis and secretion are raised by glucose injection at a dose of 300 mg%. An increase in the dose up to 600 mg% results in the suppression of insulocyte functional activity. The obtained cultures can be used for the treatment of diabetes mellitus.
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