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  • Title: [Preoperative treatment with UFT for patients with ovarian malignant tumors].
    Author: Nagai S, Sawada T, Tsukasaki K, Kamiya H, Sakai K.
    Journal: Gan To Kagaku Ryoho; 1985 May; 12(5):1073-9. PubMed ID: 3922309.
    Abstract:
    A 300-mg dose of UFT was administered daily for seven days prior to surgery for ovarian malignant tumors. The concentrations of FT, 5-FU and uracil in the serum, tumor tissue, adjacent normal tissue and ascitic fluid were measured. The results were as follows: 5-FU concentration in the serum was 0.008 +/- 0.006 micrograms/ml (n = 14) and the concentration in the ascitic fluid was 0.008 +/- 0.006 micrograms/ml (n = 4). The 5-FU concentration in the tumor tissue was 0.142 +/- 0.199 micrograms/g. This was approximately 3.0 times higher than the concentration in the adjacent normal tissue which was 0.048 +/- 0.030 micrograms/g and the T/B ratio (formula; see text) was approximately 17.8.
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