These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Site- and Enantioselective Homobenzylic C(sp3)-H Borylation via Dehydrogenation of Alkyl Chains.
    Author: Tao R, Liu G, Huang Z.
    Journal: Org Lett; 2024 Sep 13; 26(36):7626-7631. PubMed ID: 39225696.
    Abstract:
    A one-pot, dehydrogenation-based Ir/Co/Cu triple catalysis has been developed for formal asymmetric borylation of homobenzylic C(sp3)-H bonds, furnishing enantioenriched organoboronates with a β-stereocenter directly from simple arylalkanes. Mechanistic studies indicate that the Ir catalyst is responsible for dehydrogenation of arylalkanes to 1-arylalkenes, followed by Cu-catalyzed regio- and enantioselective protoboration of (E)-arylalkenes; the introduction of Co-catalyzed stereoisomerization of the (Z)-alkenes to (E)-isomers was found to have a beneficial effect on the productivity and enantioselectivity.
    [Abstract] [Full Text] [Related] [New Search]