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  • Title: A Chinese hamster ovary cell mutant resistant to aphidicolin.
    Author: Smith DB, Mishra NC.
    Journal: Cell Biol Int Rep; 1985 Apr; 9(4):331-9. PubMed ID: 3922633.
    Abstract:
    A triple (aphr ara-Ar and araCr) mutant (AP7) of Chinese hamster ovary cells resistant to DNA polymerase inhibitors is described. The aphidicolin-resistance of the mutant was stable and inherited as a dominant genetic trait. The DNA polymerase alpha from the wild type (aphs) and the mutant (aphr) cells differed in their elution profiles on DEAE-cellulose chromatography and in their molecular weights which were 192,000 for the wild type (CHO-K-1, AC6a) and 165,000 for the mutant (AP7) enzymes.
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