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  • Title: The antral gastrin-producing cells in duodenal ulcer patients. An ultrastructural study before and during treatment with cimetidine.
    Author: Nielsen HO, Hage E.
    Journal: Virchows Arch A Pathol Anat Histopathol; 1985; 406(3):271-7. PubMed ID: 3923703.
    Abstract:
    Ultrastructural examination of the antral G cells has been carried out on 11 patients with chronic duodenal ulcer, before and after treatment with a histamine H-2 - receptor antagonist (cimetidine 1 g/day) for 8 weeks. The study demonstrated an increased area of the Golgi complex, rough endoplasmic reticulum and electron-dense granules, indicating increased G cell activity during treatment. An increased number of lysosomes was a constant feature during treatment. As an hypothesis we suggest that these lysosomes may participate in the secretory mechanism of human G cells, by destroying superfluous (Gastrin) components produced during hyperactivity.
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