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  • Title: Inhibition of gluconeogenesis by 2,5-anhydro-D-mannitol in isolated rat hepatocytes.
    Author: Stevens HC, Covey TR, Dills WL.
    Journal: Biochim Biophys Acta; 1985 Jun 30; 845(3):502-6. PubMed ID: 3924119.
    Abstract:
    2,5-Anhydro-D-mannitol inhibited glucose synthesis, increased the pyruvate/phosphoenolpyruvate ratio and altered adenine nucleotide concentrations in hepatocytes isolated from fasted rats. The accumulations of 2,5-anhydro-D-mannitol 1,6-diphosphate, an allosteric activator of pyruvate kinase, and of ADP in treated hepatocytes can account for the increase in pyruvate/phosphoenolpyruvate ratio and the inhibition of glucose synthesis from lactate.
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