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  • Title: Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.
    Author: Kirkman RL, Barrett LV, Gaulton GN, Kelley VE, Ythier A, Strom TB.
    Journal: J Exp Med; 1985 Jul 01; 162(1):358-62. PubMed ID: 3925068.
    Abstract:
    Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.
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