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  • Title: Sensitization of rotational behavior produced by a single exposure to cocaine.
    Author: Guan LC, Robinson TE, Becker JB.
    Journal: Pharmacol Biochem Behav; 1985 May; 22(5):901-3. PubMed ID: 3925466.
    Abstract:
    In rats with a unilateral 6-OHDA lesion of the substantia nigra a single exposure to cocaine significantly enhanced the ipsiversive rotational behavior produced by a second injection given one week later. It is concluded that it is not necessary to repeatedly administer psychomotor stimulant drugs to produce long-lasting changes in brain and behavior.
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