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  • Title: Effect of intravenous aminophylline upon the incremental exercise performance of healthy men.
    Author: Elliott CG, Nietrzeba RM, Adams TD, Crapo RO, Jensen RL, Yanowitz FG.
    Journal: Respiration; 1985; 47(4):260-6. PubMed ID: 3925513.
    Abstract:
    Aminophylline increases the contractile force of fatiguing muscles. The effects of aminophylline upon maximal exercise performance are not defined. 6 healthy men performed incremental bicycle ergometry before and after receiving intravenous aminophylline (6 mg/kg). Maximal oxygen uptake, maximum work rate, and maximum minute ventilation were unchanged following aminophylline. Heart rate measured at rest and at 50-watt increments of work rate was significantly increased following aminophylline (p less than 0.03). The heart rate response to incremental exercise (delta HR/delta VO2) was unchanged by aminophylline. We conclude that aminophylline does not increase maximal exercise performance of healthy men.
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