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  • Title: HLA antigens in hemophiliacs A with or without factor VIII antibodies in a Venezuelan Mestizo population.
    Author: Simonney N, De Bosch N, Argueyo A, Garcia E, Layrisse Z.
    Journal: Tissue Antigens; 1985 Apr; 25(4):216-9. PubMed ID: 3925592.
    Abstract:
    Twenty-eight unrelated hemophilia A patients, seven of them with anti-factor VIII antibodies were typed for HLA-A, B, C antigens and 25 of them for HLA-DR. The results show a significant difference in HLA-DR4 frequency between hemophiliacs with antibodies who lack this antigen and hemophiliacs without antibodies, in whom HLA-DR4 is increased as compared to a healthy control series. This data suggests that DR4 may be associated with a factor preventing anti-factor VIII immunization.
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