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  • Title: Convulsive syndrome induced by the intracerebroventricular injection of alpha-difluoromethylornithine in rats.
    Author: Genedani S, Bernardi M, Botticelli A, Bertolini A.
    Journal: Acta Pharmacol Toxicol (Copenh); 1985 Mar; 56(3):250-3. PubMed ID: 3925717.
    Abstract:
    In adult rats, the intracerebroventricular injection of alpha-difluoromethylornithine (DFMO), a polyamine antimetabolite which specifically inhibits ornithine-decarboxylase, induces a typical convulsive syndrome (ED50 = 100 micrograms/rat) and death (LD50 = 300 micrograms/rat). Histological lesions are seen only with the highest doses and are essentially restricted to the Ammon's horn neurones. Since DFMO is currently undergoing clinical trials for use in cancer chemotherapy, including brain tumours, its CNS toxicity should be carefully considered.
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