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  • Title: Binding of an aldose reductase inhibitor to renal glomeruli.
    Author: Cohen MP, Klepser H.
    Journal: Biochem Biophys Res Commun; 1985 Jun 14; 129(2):530-5. PubMed ID: 3925947.
    Abstract:
    The aldose reductase inhibitor Sorbinil affects several membrane-associated complexes including Na/K-ATPase activity, transport processes, and impulse propagation. These considerations, coupled with the drug's aromatic nature, suggested the possibility of direct interaction with cell membranes. In the present study, binding of [3H]-Sorbinil to isolated glomeruli was demonstrated. Binding is dose-dependent and saturable, and can be inhibited by increasing concentrations of unlabeled Sorbinil. These results may help explain the compound's diverse effects on membrane-associated processes.
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